Tiloram pills 125mg, 10pcs

Composition

Composition per tablet: Active ingredient:  tilorone dihydrochloride (tilorone) -125.0 mg. excipients (core): lactose monohydrate (milk sugar) -101,0 mg, microcrystalline cellulose – 45,0 mg, Crocker chalk vine sodium – 9.0 mg, water – 5.0 mg, povidone-To 17 – 12,0 mg, magnesium stearate – 3,0 mg. excipients (shell): hypromellose – 5,7 mg, macrogol-4000 – 1.4 mg, titanium dioxide – 2,8 mg, dye tropaeolin-0 – 0.1 mg

Pharmacological action

Low molecular weight synthetic interferon inducer that stimulates the formation of interferons alpha, beta and gamma in the body. The main producers of interferon in response to the introduction of tiloron are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral use, the maximum production of interferon is determined in the gut – liver – blood sequence after 4-24 hours. Tiloron has an immunomodulatory and antiviral effect. In human leukocytes, it induces the synthesis of interferon. It stimulates bone marrow stem cells, increases antibody formation depending on the dose, reduces the degree of immunosuppression, and restores the ratio of T-suppressors and T-helpers. It is effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed.

Pharmacokineticsafter oral use, it is rapidly absorbed from the gastrointestinal tract. Bioavailability -60%. About 80% of the drug binds to plasma proteins. The drug is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). The half – time period is 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.

Indications

• Treatment and prevention of influenza, and other acute respiratory viral infections (ARVI);
• treatment of viral hepatitis A, b and C;
• the treatment of herpes and cytomegalovirus infection;
• in the complex therapy of infectious-allergic and viral encephalomyelitis (multiple sclerosis, leukoencephalitis, avioanele, etc. );
• in the complex therapy of urogenital and respiratory chlamydia; in the complex therapy of pulmonary tuberculosis.

Contraindications

Hypersensitivity to tilorone and other components of the drug.

• the period of pregnancy and lactation.
• children under 18 years of age.
• hereditary problems of lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

With caution in the complex therapy of infectious-allergic and viral encephalomyelitis, the drug is used under the supervision of a doctor.

Side effects

Possible allergic reactions, dyspeptic phenomena, short-term chills.

Interaction

It is compatible with antibiotics and drugs for the traditional treatment of viral and bacterial diseases. There was no clinically significant interaction of tilorone with antibiotics and traditional treatment of viral and bacterial diseases, as well as alcohol.

How to take, course of use and dosage

Tiloron is taken orally, after meals. For the treatment of viral hepatitis A – on the first day,125 mg 2 times, then 125 mg after 48 hours. For the exchange rate of -1.25 g. For the treatment of acute hepatitis B-125 mg for the first two days, then 125 mg after 48 hours, for the course of treatment-2 g. With a prolonged course of hepatitis B-125 mg 2 times a day on the first day, then 125 mg after 48 hours. For the course of treatment – 2.5 g. In chronic hepatitis B-the initial phase of treatment (2.5 g) – the first two days of 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (from 1.25 g to 2.5 g),125 mg per week. The course dose of tiloron is from 3.75 g to 5 g, the duration of therapy is 3.5-6 months, depending on the results of biochemical, immunological, and morphological studies that reflect the degree of activity of the process. In acute hepatitis C – 125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The course of treatment is 2.5 g. In chronic hepatitis C – the initial phase of treatment (2.5 g) – the first two days of 125 mg 2 times a day, then 125 mg after 48 hours. Continuation phase (2.5 g) 125 mg per week. The course dose of tiloron is 5 g, the duration of therapy is 6 months, depending on the results of biochemical, immunological, and morphological markers of the process activity. In the complex therapy of infectious-allergic and viral encephalomyelitis – 125-250 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. The dose is set individually, the course of treatment is 3-4 weeks. For the treatment of influenza and other acute respiratory infections-125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. Per course-750 mg. For the prevention of influenza and other acute respiratory viral infections-125 mg 1 time a week for 6 weeks. Per course-750 mg. For the treatment of herpetic, cytomegalovirus infection – the first two days of 125 mg, then after 48 hours of 125 mg. The course dose is -1.25-2.5 g. For urogenital and respiratory chlamydia,125 mg for the first two days, then 125 mg after 48 hours. The course dose is 1.25 g. In complex therapy of pulmonary tuberculosis-250 mg for the first two days of treatment, then 125 mg after 48 hours. The course dose is 2.5 g.

Special instructions

Effect on the ability to drive vehicles and work with mechanisms There are no data on the effect of the drug on the ability to drive a car and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions in the recommended doses.

Storage conditions

In a dark place at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Tiloron

Dosage form

Tablets

Description

For adults

Indications

Flu, Cytomegalovirus infection, Hepatitis, Chlamydia, Herpes, Common cold, Flu and cold prevention, Tuberculosis