Tizalud, pills 2mg, 30pcs

Composition

1 tablet contains:

active ingredients:

tizanidine – 2 mg

. excipients:

anhydrous lactose (lactopress),

microcrystalline cellulose,

sodium carboxymethyl starch (primogel),

magnesium stearate.

Pharmacological action

Tizalud is a central-acting muscle relaxant.

The main point of application is in the spinal cord. By stimulating presynaptic alpha-2 adrenergic receptors, tizanidine suppresses the release of excitatory amino acids from intermediate neurons of the spinal cord, which leads to inhibition of polysynaptic transmission of arousal in the spinal cord. As a result, there is a decrease in muscle tone. In addition to its muscle-relaxing properties, tizanidine also has a central moderate analgesic effect.

It is effective against acute painful muscle spasms and chronic spasms of spinal and cerebral origin. Reduces spasticity and clonic seizures, which reduces resistance to passive movements and increases the volume of active movements.

Indications

Spastic state of skeletal muscles caused by neurological diseases (multiple sclerosis, chronic myelopathy, stroke, degenerative diseases of the spinal cord).

Painful spasm of skeletal muscles caused by damage to the spine (cervical and lumbar syndromes) or occurring after surgery (for a herniated disc or hip osteoarthritis).

Use during pregnancy and lactation

Since no controlled studies have been conducted on the use of tizanidine in pregnant women, it should not be used during pregnancy, unless the expected benefit to the mother exceeds the possible risk to the fetus. isanidine is excreted in breast milk in small amounts.

However, if it is necessary to use tizanidine during lactation, the question of stopping breastfeeding should be decided.

Contraindications

Hypersensitivity to tizanidine.

Use in patients with liver function disorders

Use with caution in patients with impaired liver function.

Use in patients with impaired renal function

Use with caution in patients with impaired renal function.

Side effects

Nervous system disorders:  drowsiness, dizziness, hallucinations, insomnia, sleep disorders.

From the cardiovascular system:  bradycardia, decreased blood pressure (in some cases pronounced, up to collapse and loss of consciousness).

From the digestive system:  dry mouth, nausea, dyspepsia, increased activity of “liver” transaminases, hepatitis, liver failure.

From the musculoskeletal system:  muscle weakness.

Other services:  increased fatigue, hypercreatininemia.

In case of abrupt withdrawal after prolonged treatment and / or taking high doses of the drug (as well as after simultaneous use with antihypertensive drugs): tachycardia, increased blood pressure, in some cases – acute violation of cerebral circulation.

Interaction

Concomitant use of tizanidine with fluvoxamine or ciprofloxacin, inhibitors of cytochrome P450 isoenzyme 1A2, resulted in a 33-fold increase in tizanidine AUC. The result of combined use may be a clinically significant and prolonged decrease in blood pressure, leading to drowsiness, weakness, inhibited psychomotor reactions (in some cases, up to collapse and loss of consciousness).

Concomitant use of tizanidine with other inhibitors of the CYP1A2 isoenzyme-antiarrhythmic drugs (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (enoxacin, pefloxacin, norfloxacin), rofecoxib, oral contraceptives, ticlopidine-is not recommended.

Antihypertensive medications increase the risk of a marked decrease in blood pressure and bradycardia. Ethanol, sedative drugs can increase the sedative effect of tizanidine, so simultaneous use with other sedatives and/or alcohol is not recommended.

How to take, course of use and dosage

For relief of painful muscle spasms:  inside,2-4 mg 3 times a day, in severe cases-an additional 2-4 mg at night.

For the treatment of spasticity caused by neurological diseases:  the initial dose is 2 mg 3 times a day, then the dose is gradually increased by 2-4 mg at intervals of 3-7 days. The optimal daily dose is 12-24 mg in 3-4 divided doses; the maximum daily dose is 36 mg.

Patients with renal insufficiency:  if creatinine clearance is less than 25 ml / min, the recommended initial dose is 2 mg once a day. Increasing the dose is carried out gradually, slowly, taking into account tolerability and effectiveness.

If you need to get a more pronounced effect, it is recommended to first increase the dose prescribed once a day, then increase the frequency of use.

Overdose

Symptoms:  nausea, vomiting, marked decrease in blood pressure, dizziness, drowsiness, miosis, anxiety, respiratory disorders, coma.

Treatment:  gastric lavage, use of activated charcoal, forced diuresis, symptomatic therapy.

Special instructions

Use with caution in patients with impaired liver and kidney function.

Influence on the ability to drive motor vehicles and manage mechanisms

At the beginning of treatment, if drowsiness occurs, you should avoid activities that require high concentration of attention, rapid psychomotor reactions.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Tizanidine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Lumbago, Sciatica, Muscle Spasm, Sciatica, Osteochondrosis