Tocopherol acetate, capsules 0.1g, 10pcs

Product description

dietary supplements. It is not a medicinal product

Composition

1 capsule. contains: Active ingredients: Vitamin E (tocopherol acetate) 100 mg, Excipients: sunflower oil – 100 mg. Capsule shell composition:  gelatin – 44.73 mg, glycerol-14.67 mg, methyl parahydroxybenzoate-0.29 mg, dye azorubin-0.31 mg

Pharmacological action

ATX code: A 11 TO 03Pharmacological action Vitamin E is an antioxidant. Protects the cell membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes-hemoglobin, myoglobin, cytochromes, catalase, peroxidase. Inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits cholesterol synthesis. Prevents hemolysis of red blood cells, increased permeability and fragility of capillaries, impaired function of seminal tubules and testicles, placenta, normalizes reproductive function. Pharmacokineticabsorption from duodenum 12 (requires the presence of bile salts, fats, normal pancreatic function) – 50-80%. Binds to blood beta-lipoproteins. When protein metabolism is disrupted, transport becomes difficult. Tsmakh -4 hours. It is deposited in all organs and tissues, especially in adipose tissue. Penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the mother’s blood penetrates into the fetal blood. Penetrates into breast milk. It is metabolized in the liver to derivatives with a quinone structure (some of them have vitamin activity). It is excreted with bile-more than 90% (some amount is reabsorbed and undergoes enterohepatic circulation), kidneys-6% (in the form of tocopheronic acid glucuronides and its gamma-lactone).

Indications

Hypovitaminosis E. In complex therapy: muscular dystrophy; dermatomyositis; atherosclerosis, myocardial dystrophy; menstrual disorders; threats of termination of pregnancy, disorders of the sex glands in men; dermatoses, psoriasis.

Contraindications

Increased individual sensitivity to the components of the drug, acute myocardial infarction, childhood.

With caution: hypoprothrombinemia, severe cardiosclerosis, previous myocardial infarction, increased risk of thromboembolism.

Side effects

Possible allergic reactions, dyspepsia.

Interaction

Vitamin E enhances the effect of glucocorticosteroid medications, nonsteroidal anti-inflammatory drugs, and cardiac glycosides. Reduces the effectiveness and toxicity of vitamins A and D. Increases the effectiveness of antiepileptic drugs in patients with epilepsy. Concomitant use of other multivitamin complexes containing vitamin E is not recommended to avoid overdose. Concomitant use of high doses of vitamin E with iron, vitamin K, or anticoagulants (agents that prevent blood clotting) increases blood clotting time.

How to take, course of use and dosage

Inside 100-300 mg / day, if necessary up to 1 g / day. For diseases of the neuromuscular system-100 mg per day for 1-2 months. Repeat courses in 2-3 months. For disorders of spermatogenesis and potency – 100-300 mg per day in combination with hormone therapy for a month. In case of threatened abortion-100 mg per day for 7-14 days, in case of habitual abortion and deterioration of intrauterine development of the fetus-100 mg per day for the first 2-3 months of pregnancy daily or every other day. For peripheral vascular diseases, myocardial dystrophy, atherosclerosis-100 mg per day (with vitamin A) for 20-40 days, after 3-6 months, the course of treatment can be repeated. In dermatology – 100 mg per day for 20-40 days.

Overdose

Symptoms: when taking vitamin E for a long period in doses of 400-800 mg / day: – blurred vision, dizziness, headache, nausea, fatigue, diarrhea, gastralgia, asthenia. When taking more than 800 mg / day for a long period – an increased risk of bleeding in patients with hypovitaminosis K, impaired thyroid hormone metabolism, sexual function disorders, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites. Treatment: symptomatic. Drug withdrawal, use of glucocorticosteroid medications.

Storage conditions

Store in a dry place protected from light at a temperature not exceeding 25 °C. Keep out of reach of children.

Shelf

life is 2 years. Do not use after the expiration date.

Conditions of release from pharmacies

Without a prescription

Dosage form

Capsules