Tocopherol acetate (vitamin E), 30% dropper bottle, 50ml

Composition

: 30% tocopherol acetate oil solution.

Pharmacological action

Vitamin E is a natural antioxidant.

Protects the cell membranes of body tissues from oxidative changes; stimulates the synthesis of gemma and gem-containing enzymes-hemoglobin, myoglobin, cytochromes, catalase, peroxidase.

Inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits cholesterol synthesis.

Prevents hemolysis of red blood cells, increased permeability and fragility of capillaries, impaired function of the seminal tubules and testicles, placenta, normalizes reproductive function; prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles.

Indications

Hypovitaminosis E; a comprehensive treatment of conditions involving an increased need for vitamin E: with muscular dystrophy, ringworm, amyotrophic lateral sclerosis, and asthenia neurasthenic syndrome, fatigue, paresis, myasthenic, myopathies, disorders of the menstrual cycle, the threat of termination of pregnancy, menopause, impaired function of the sexual glands in men and women;

when dermatosis, psoriasis;

atrophy of the mucosa of the respiratory tract, periodontal disease;

rheumatic diseases: fibrositic, tendopathy, diseases of joints and spine;

with endocrine disease: hyperthyroidism, diabetes, especially with ketoacidosis, diabetic polyneuropathy;

the syndrome of malabsorption, chronic liver disease;

if myocardiodystrophy, peripheral vascular spasm.

In a state of convalescence after diseases that occurred with febrile syndrome.

Contraindications

Increased individual sensitivity to the drug.

With caution: hypoprothrombinemia (against the background of vitamin K deficiency – may increase with a dose of vitamin E more than 400 IU), severe coronary artery atherosclerosis, myocardial infarction, increased risk of thromboembolism.

Side effects

Allergic reactions.

The use of high doses of the drug can cause dyspeptic disorders, decreased performance, weakness, thrombophlebitis, pulmonary embolism, thrombosis, increased creatine kinase activity, creatinuria, hypercholesterolemia, white hair growth in areas of alopecia with vesicular epidermolysis.

Interaction

Increases the effect of glucocorticosteroid drugs, nonsteroidal anti-inflammatory drugs, and antioxidants.

Increases the effectiveness and reduces the toxicity of vitamins A, D, and cardiac glycosides.

Taking vitamin E in high doses can cause vitamin A deficiency in the body.

Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased blood levels of lipid peroxidation products).

Concomitant use of vitamin E at a dose of more than 400 U / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding.

Colestyramine, colestipol, mineral oils reduce absorption.

High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

How to take, course of use and dosage

For oral use, the drug is prescribed in the following doses: :

For diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc. ),50-100 mg per day (50-100 drops of 5% solution,25-30 drops of 10% solution or 7-15 drops of 30% solution) for 1-2 months. Repeat courses in 2-3 months.

Men with disorders of spermatogenesis and potency: 100-300 mg per day (100-300 drops of 5% solution,50-150 drops of 10% solution or 15-46 drops of 30% solution) in combination with hormone therapy for a month.

In case of threatened abortion,100-150 mg per day (100-150 drops of 5% solution,50-75 drops of 10% solution or 15-23 drops of 30% solution). In case of habitual abortion and deterioration of intrauterine development of the fetus,100-150 mg per day (100-150 drops of 5% solution,50-75 drops of 10% solution or 15-23 drops of 30% solution) in the first 2-3 months of pregnancy daily or every other day.

For peripheral vascular diseases, myocardial dystrophy, atherosclerosis,100 mg per day (100 drops of 5% solution,50 drops of 10% solution or 15 drops of 30% solution) in combination with vitamin A. The course duration is 20-40 days, after 3-6 months the course of treatment can be repeated.

For skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution,7-50 drops of 10% solution or 2-5 drops of 30% solution) for 20-40 days.

1 drop from an eye pipette contains: α-Tocopherol acetate in a 5% solution – 1 mg, in a 10% solution-2 mg; in a 30% solution-6.5 mg.

Overdose

Symptoms: when taken for a long period at doses of 400-800 U/day (1 mg = 1.21 IU) – blurred visual perception, dizziness, headache, nausea, extreme fatigue, diarrhea, gastralgia, asthenia, when taken more than 800 U/day for a long period – increased risk of bleeding in patients with hypovitaminosis K, impaired thyroid hormone metabolism, sexual function disorders, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites.

Treatment: symptomatic, drug withdrawal, use of glucocorticosteroid drugs.

Special instructions

It should be borne in mind that in newborns with low body weight, hypovitaminosis E may occur due to low placental permeability (the fetal blood contains only 20-30% of vitamin E from its concentration in the mother’s blood).

A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E.

Form of production

The solution for oral use is oil.

Storage conditions

The drug should be stored in a cool, dry place out of the reach of children.

Shelf

life is 2 years.

Active ingredient

Vitamin E