Tolperisone-OBL, pills 50mg 30pcs

Composition

1 tablet contains:

Active ingredient:

Tolperisone hydrochloride — 50 mg (for a dosage of 50 mg) or 150 mg (for a dosage of 150 mg);

excipients:

citric acid,

lactose monohydrate (milk sugar),

hyprolose (hydroxypropylcellulose),

crospovidone,

stearic acid

shell excipients:

Opadray II (Series 85) [polyvinyl alcohol, macrogol (polyethylene glycol), talc, titanium dioxide]

Pharmacological action

Pharmacodynamics  Tolperisone is an OBL-based muscle relaxant with a central mechanism of action. It has a membrane-stabilizing effect, inhibits the conduction of nerve impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono – and polysynaptic reflexes. It probably mediates the blocking of neurotransmitter release by inhibiting Ca+2 entry into synapses. Inhibits the conduction of excitation along the reticulospinal pathway in the brain stem. Regardless of the influence of the central nervous system, it increases peripheral blood flow. A weak antispasmodic and antiadrenergic effect of Tolperisone may play a role in the development of this effect. Pharmacokinetics After oral use, Tolperisone is well absorbed from the small intestine. The maximum concentration in blood plasma is reached in 30 minutes-1 hour after use, bioavailability due to pronounced presystemic metabolism is about 20%. Tolperisone is extensively metabolized in the liver and kidneys. It is excreted in the urine almost exclusively (more than 99%) in the form of metabolites. The pharmacological activity of the metabolites is unknown.

Indications

Treatment of pathologically increased tone and spasms of striated muscles caused by organic neurological pathology (including damage to the pyramidal pathways, multiple sclerosis, stroke, myelopathy, encephalomyelitis).

Treatment of increased muscle tone and spasms, muscle contractures accompanying diseases of the musculoskeletal system (spondylosis, spondyloarthrosis, arthrosis of large joints, cervical and lumbar pain syndromes).

Rehabilitation treatment after surgical interventions in orthopedics and traumatology.

As part of the combination therapy of obliterating vascular diseases (obliterating atherosclerosis, diabetic angiopathy, obliterating thrombangiitis, Raynaud’s disease), as well as diseases that occur due to a violation of vascular innervation (acrocyanosis, intermittent angioedema).

Contraindications

• of myasthenia gravis,
• hypersensitivity to the components of the drug.

Due to the presence of lactose in the composition, patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take the drug.

Side effects

• muscle weakness,
• headache,
• hypotension,
• nausea,
• vomiting,
• gastralgia (usually go away with a reduced dose),
• rarely-hypersensitivity reactions (pruritus, erythema, urticaria, angioedema, bronchospasm, anaphylactic shock).

Interaction

Tolperisone has an effect on the central nervous system, but does not cause sedation, so it can be used in combination with sedatives, sleeping pills, and tranquilizers. It does not increase the effect of alcohol on the central nervous system.

Increases the severity of the action of niflumic acid, so when they are used simultaneously, you can reduce the dose of the latter.

medications for general anesthesia, peripheral muscle relaxants, psychoactive drugs, clonidine enhance the effect.

How to take, course of use and dosage

Inside.

For adults, the initial dose is 50 mg 2-3 times a day, with a gradual increase to 150 mg 2-3 times a day.

The duration of treatment depends on the severity and nature of the course of the disease.

Overdose

Symptoms: respiratory and cardiac depression, decreased blood pressure.

Treatment: symptomatic.

Special instructions

During the treatment period, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Film-coated tablets.

Storage conditions

Keep out of reach of children in a dry place protected from light and at a temperature not exceeding 25 ° C.

Shelf

life is 2 years.

Active ingredient

Tolperisone

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Children over 3 years of age, Children as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Osteoarthritis, Stroke Effects, Osteoarthritis, Sciatica, Muscle Spasm, Arthritis, Lumbago