Travatan eye drops 40mcg/ml 2.5ml vial dropper, 1pc

Composition

Active ingredient:

travoprost 0.04 mg;

Auxiliary substances:

macrogol glycerylhydroxystearate (also known as polyoxyethylene hydrogenated castor oil 40 — HCO — 40);

benzalkonium chloride solution (equivalent to benzalkonium chloride);

disodium edetate;

boric acid;

trometamol;

mannitol;

sodium hydroxide and / or concentrated hydrochloric acid — to adjust the pH;

water is purified.

Pharmacological action

Travatan has an anti-glaucomatous effect. The main Active ingredient of the drug, travoprost, is a synthetic analog of prostaglandin F2-alpha, which selectively activates FP-receptors of the ciliary body and causes an increased outflow of intraocular fluid filling the space between the lens and cornea, which is accompanied by a decrease in intraocular pressure. Travatan mainly enhances the uveoscleral outflow pathway of aqueous humor, without noticeably affecting the production of intraocular fluid.

The anti-glaucoma effect of travoprost is manifested approximately 120 minutes after instillation of the drug, the maximum antihypertensive effect develops within 12 hours.

Pharmacokinetics

Absorption and metabolism

Travoprost is absorbed through the cornea of the eye, where it is hydrolyzed to a biologically active form – travoprost acid.

Cmax of travoprost in blood plasma is reached within 30 minutes after topical application and is 25 pg / ml or less.

Deduction

Travoprost is rapidly eliminated from the plasma, and within an hour the concentration decreases below the detection threshold (

Travoprost is excreted as inactive metabolites mainly in the bile (61%), the rest is excreted by the kidneys.

Indications

Travatan is used in the complex therapy of open-angle glaucoma, as well as to reduce intraocular pressure in patients with increased ophthalmotonus.

Use during pregnancy and lactation

Travatan is contraindicated in women during pregnancy.

There is no sufficient experience with the use of the drug during breast-feeding. It is possible to use Travatan for the treatment of nursing mothers as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of possible side effects for the child.

Use in children

The drug is contraindicated in children and adolescents under 18 years of age.

Contraindications

Travatan eye drops are not used when individual hypersensitivity to the components of the drug appears, during pregnancy and during breastfeeding, as well as for the treatment of patients under 18 years of age.

With caution: risk factors for macular edema (aphakia, pseudophakia, damage to the posterior lens capsule), acute iritis, uveitis.

Side effects

In 35% of cases, there is a transient mild conjunctival hyperemia, which passes without additional therapy over time.

In 5-10% of cases — a decrease in visual acuity, a feeling of discomfort and “foreign body feeling”, pain, itching, burning in the eyes. In 1-4% of cases — visual disorders, blepharitis, ” fog ” in front of the eyes, cataracts, conjunctivitis, dry conjunctiva, changes in the color of the iris, keratitis, crusting on the edges of the eyelids, photophobia, subconjunctival hemorrhages and increased lacrimation.

Systemic side effects are observed in 1-5% of cases: general anxiety, headache, depression, increased or decreased blood pressure, bradycardia, angina pectoris, chest pain, arthritis, back pain, flu-like syndrome, sinusitis, bronchitis, hypercholesterolemia, dyspepsia, urinary incontinence and urinary system infections.

Interaction

Travatan can be used in combination with other topical ophthalmic medications to reduce intraocular pressure.

In this case, the interval between their use should be at least 5 minutes.

How to take, course of use and dosage

Into the conjunctival sac. Take 1 drop 1 time a day, in the evening. More frequent use of the drug may lead to a decrease in its effectiveness.

Overdose

Symptoms: irritation of the eye mucosa, hyperemia of the conjunctiva or episclera.

Treatment: symptomatic.

Special instructions

Permanent heterochromia can result from treating only one eye.

In the presence of nevi or lentigo on the iris, their changes under the influence of the drug were not noted.

The drug may cause darkening, thickening and lengthening of the eyelashes and/or an increase in their number; rarely – darkening of the skin of the eyelids.

If Travatan is used with other topical anti-glaucoma drugs, the interval between their use should be at least 5 minutes.

It is recommended to remove contact lenses without fail before using the drug, in order to avoid violating the transparency of contact lenses. Install them back no earlier than 20 minutes after the procedure.

The bottle must be closed after each use.

The drug can cause a gradual change in eye color due to an increase in the amount of brown pigment in the iris. This effect is detected mainly in patients with mixed color of the iris, for example, blue-brown, gray-brown, green-brown or yellow-brown, which is explained by an increase in the content of melanin in the stromal melanocytes of the iris. Usually, brown pigmentation spreads concentrically around the pupil to the periphery of the iris, and the entire iris or parts of it may turn a more intense brown color.

In patients with evenly colored blue, gray, green, or brown eyes, changes in eye color after two years of using the drug were very rare. The color change is not accompanied by any clinical symptoms or pathological changes.

After discontinuation of the drug, there was no further increase in the amount of brown pigment, but the color change that has already developed may be irreversible.

Before starting treatment, patients should be informed about the possibility of changing eye color.

Form of production

Eye drops

Storage conditions

At a temperature of 2-25 °C

Shelf life

3 years

Active ingredient

Travoprost

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

For adults as directed by your doctor

Indications

Glaucoma