Trialgin pills, 20pcs

Composition

Metamizole sodium-300 mg; Phenobarbital-10 mg; Caffeine-50 mg

Pharmacological action

Pharmacological action

Combined analgesic.

Component Properties

Caffeine-increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, expands the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue, increases mental and physical performance.

Pharmacodynamics

It has analgesic and antipyretic effects. The analgesic effect develops in 20-30 minutes and reaches a maximum in 45 minutes Pharmacological properties are determined by the action of the components included in the combination.

Indications

• Headache;
• toothache; muscle and joint pain;
• painful menstruation;
• sciatica, neuralgia.

Contraindications

• Hypersensitivity to Metamizole sodium and other pyrazolone derivative and pyrazolidine, such as phenylbutazone (including patients with agranulocytos due to the use of these drugs), caffeine, phenobarbital or other components of the drug;
• analgesic asthma or intolerance to analgesics (by type of urticaria-angioedema), i. e. patients with bronchospasm or other forms of anaphylactoid reactions (e. g., urticaria, rhinitis, angioedema) in response to the use of salicylates, paracetamol or non-steroidal anti-inflammatory drugs such as diclofenac, ibuprofen, Indometacin, Linapacan;
• violation of bone marrow hematopoiesis (e. g., after cytostatic therapy), or diseases of the blood-forming organs;
• hereditary deficiency of glucose-6-phosphate dehydrogenase (hemolysis);
• acute intermittent hepatic porphyria (risk of attacks of porphyria);
• severe liver disease and/or kidney disease;
• respiratory diseases, accompanied by shortness of breath or obstruction of the respiratory tract;
• myasthenia gravis;
• alcohol, drug or substance abuse, including in the anamnesis;
• pregnancy and lactation;
• children up to age 18 years.

With caution

Impaired liver and/or kidney function, gastric and duodenal ulcers in remission, glaucoma, increased excitability, advanced age, epilepsy, and a tendency to convulsive seizures.

Side effects

To date, no side effects have been reported with this combination. The frequency of occurrence of the following possible side effects is unknown. When using the drug in accordance with the instructions, the occurrence of the following side effects is unlikely.

From the immune system:  angioedema, anaphylactoid and anaphylactic reactions.

From the side of hematopoietic organs:  agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, pancytopenia.

Nervous system disorders:  psychomotor agitation, anxiety, tremor, restlessness, dizziness, epileptic seizures, increased reflexes, insomnia; paradoxical reaction in the elderly (unusual agitation), increased fatigue, drowsiness, decreased speed of psychomotor reactions, drug dependence.

From the cardiovascular system:  palpitation, tachycardia, increased blood pressure, decreased blood pressure.

Respiratory, thoracic and mediastinal disorders:  tachypnea, bronchospastic syndrome, analgesic bronchial asthma.

From the digestive system:  nausea, vomiting, exacerbation of peptic ulcer disease (caffeine), constipation.

Skin and subcutaneous tissue disorders:  rash (including persistent), pruritus, urticaria.

If you experience any adverse reactions, including those not specified in the instructions, you should consult your doctor.

How to take, course of use and dosage

Inside but 1 tab. 1-4 times/day. Tablets should be swallowed whole, washed down with a sufficient amount of liquid.

The maximum daily dose is 4 tablets. The duration of admission is not more than 5 days.

Elderly patients, patients with a severe general condition and impaired creatinine clearance should reduce the dose, as they may have reduced excretion of metamizole sodium and phenobarbital metabolites.

Since the elimination rate of the drug decreases in patients with impaired renal or hepatic function, repeated use of high doses should be avoided. With short-term use, no dose reduction is required. There is no experience of long-term use.

Storage conditions

The drug should be stored in a dry place, protected from light and inaccessible to children, at a temperature not exceeding 25°C.

Shelf

life is 3 years.

Active ingredient

Caffeine, Metamizole Sodium, Phenobarbital

Dosage form

Tablets