Trombless, gel 1 ths.me/g, 50g

Composition

Gel for external use 1000 IU/g. 10,20,30,40,50 g in aluminum tubes or polyethylene laminate tubes.

Each tube together with the instructions for medical use of the drug is placed in a pack of cardboard.

1 g of gel contains:

Active ingredient:  

Sodium heparin-1000 IU (0.00833 g with the activity of sodium heparin 120 IU / mg);

Auxiliary substances:  

Ethanol (ethyl alcohol) — 0.24 g,

Methylparahydroxybenzoate (nipagin, methylparaben) — 0.0012 g,

Propyl parahydroxybenzoate (nipazole, propylparaben) — 0.0003 g,

Diethanolamine (2,2-iminodiethanol) – up to 0.014 g to produce a gel with a pH of 7.5 to 8.7,

Carbomer (carbopol) – up to 0.015 g,

Water (purified water) – up to 1 year.

Pharmacological action

Pharmacodynamics

A direct anticoagulant, it has anti-inflammatory, antiproliferative, decongestant and analgesic effects.

Reduces platelet aggregation, binds to antithrombin III, preventing the transition of prothrombin to thrombin. Inhibits the activity of thrombin.

Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. Trombless ® improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and

blood clots, ultimately restoring the patency of the veins, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect.

Pharmacokinetics

A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after application.

Elimination of heparin mainly occurs through the kidneys, with a half-life of 12 hours.

Indications

Thrombophlebitis of superficial veins; localized infiltrates and edema of soft tissues; subcutaneous hematomas (including hematomas after phlebectomy), injuries and bruises of joints, tendons, and muscle tissue.

Use during pregnancy and lactation

It is possible to use the drug during pregnancy and lactation, if the potential benefit to the mother outweighs the risk to the fetus and child.

Contraindications

Hypersensitivity to the components of the drug. Ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; increased tendency to bleeding, thrombocytopenia.

Side effects

With prolonged use of the drug, local reactions in the form of skin hyperemia, allergic reactions are possible.

Interaction

Concomitant use of the gel with indirect anticoagulants may cause prolongation of prothrombin time.

The gel is not prescribed topically simultaneously with nonsteroidal anti-inflammatory drugs, tetracyclines, antihistamines.

How to take, course of use and dosage

Externally. A column of gel 3-10 cm long is applied with light rubbing movements to the skin over the affected area 1-3 times a day. The gel is applied daily, on average from 3 to 7 days. The duration of treatment is determined by the doctor.

Overdose

Due to low systemic absorption, overdose is unlikely.

Description

Direct – acting anticoagulant for topical use

Description

The gel is colorless or slightly yellowish, transparent, with a specific smell.

Functional features

A small amount of heparin is absorbed from the skin surface into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after application. Elimination of heparin mainly occurs through the kidneys, with a half-life of 12 hours.

Complete set

Gel for external use 1000 IU/g. 50 g each in aluminum tubes or polyethylene laminate tubes. Each tube together with the instructions for medical use of the drug is placed in a pack of cardboard.

Special instructions

The drug should not be used for bleeding, as well as on open wounds, on mucous membranes and with purulent processes.

Form of production

The gel is colorless or slightly yellowish, transparent, with a specific smell.

Storage conditions

At a temperature not exceeding 25°C. Keep out of reach of children.

Shelf

life is 3 years. Do not use the product after the expiration date.

Active ingredient

Sodium Heparin

Dosage form

gel for external use

Description

Nursing mothers as prescribed by a doctor, For pregnant women, For adults

Indications

Varicose veins, Bruises, Dislocations and sprains, Tendon inflammation, Thrombophlebitis, Swelling after injuries and operations