Troxerutin capsules 300mg, 50pcs

Composition

Per capsule:

Active ingredient:  troxerutin – 300.0 mg.

Auxiliary substances:  lactose monohydrate (milk sugar) – 39.5 mg, sodium carboxymethyl starch-7.0 mg, magnesium stearate-3.5 mg.

Solid gelatin capsules No. 0

Capsule body composition:  iron oxide red dye – 0.0071%; iron oxide yellow dye-0.1227%; titanium dioxide-2.0000%; gelatin-up to 100%.

Capsule cap composition:  diamond blue dye – 0.0190%; charming red dye-0.0450%; titanium dioxide-3.0000%; gelatin-up to 100%.

Pharmacological action

Pharmacotherapeutic group

venotonizing and venoprotective agent

ATX Code: C05CA

Pharmacodynamics :

Flavonoid (a rutin derivative) has P-vitamin activity; has a venotonizing angioprotective anti-inflammatory and anti-edematous effect; reduces capillary permeability and fragility.

Pharmacodynamic properties are associated with the involvement of troxerutin bioflavonoids in redox processes and inhibition of hyaluronidase. By inhibiting hyaluronidase, troxerutin stabilizes the hyaluronic acid of cell membranes and reduces their permeability. It has antioxidant activity, which prevents the oxidation of ascorbic acid, epinephrine and lipids. In addition, it reduces the permeability and fragility of capillaries and prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin reduces exudative inflammation in the vascular wall by reducing platelet adhesion to its surface. Inhibits aggregation and increases the degree of deformation of red blood cells.

In chronic venous insufficiency, troxerutin reduces the feeling of heaviness and swelling in the legs, reduces the intensity of pain and cramps, and improves tissue trophism. Troxerutin relieves the symptoms associated with hemorrhoids (pain, exudation, itchy bleeding).

Troxerutin helps slow the progression of diabetic retinopathy due to its effect on the permeability and resistance of capillary walls. The effect of troxerutin on the rheological properties of blood helps prevent retinal vascular microthrombosis.

Pharmacokinetics:

Troxerutin is rapidly absorbed when the drug is taken orally. The maximum concentration of troxerutin is established on average 175±046 hours after oral use. Absorption is approximately 10-15%. The bioavailability of the drug increases with increasing dose. The elimination half-life is 677±237 hours. The therapeutic concentration of the drug in the blood plasma is maintained for 8 hours. 30 hours after taking troxerutin, the second maximum concentration of the drug in blood plasma is observed due to enterohepatic recirculation. Partially metabolized in the liver to form glucuronide and trihydroethylquercitin. Excreted mainly through the intestines (up to 65-70%) a smaller part (up to 25%) of the drug is excreted unchanged by the kidneys.

Indications

-Chronic venous insufficiency

-Postphlebitic syndrome

-Trophic disorders in leg varicose veins and trophic ulcers

– As an auxiliary treatment after sclerotherapy and / or removal of varicose veins of the lower extremities

– Post-traumatic edema and soft tissue hematomas.

– Hemorrhoids (to relieve symptoms).

– In the complex treatment of retinopathy in patients with diabetes mellitus arterial hypertension and atherosclerosis

Use during pregnancy and lactation

Teratogenicity and fetotoxicity of drugs containing troxerutin were not observed in experimental studies. Studies on the teratogenicity and fetotoxicity of Troxerutin in humans have not been conducted, but there are indications of a possible association between troxerutin use during pregnancy and anomalies of the external ear structure in children. In the first trimester of pregnancy, the use of the drug Troxerutin is contraindicated. In the second and third trimesters of pregnancy, the use of Troxerutin is possible only if the expected benefit to the mother exceeds the potential risk to the child.

There are no data on the penetration of troxerutin into breast milk. Troxerutin should not be used during breastfeeding.

Contraindications

-Hypersensitivity to troxerutin or excipients included in the drug.

– Peptic ulcer of the stomach and duodenum and chronic gastritis in the acute phase.

– Lactose intolerance-lactase deficiency or glucose-galactose malabsorption syndrome.

– Pregnancy (I trimester) and lactation.

– Children’s age (up to 18 years of experience is not enough).

With caution:

– Chronic renal failure.

Side effects

Allergic reactions: skin rashes;

From the central nervous system: headache;

From the gastrointestinal tract:  nausea vomiting stomach pain flatulence diarrhea erosive and ulcerative lesions of the gastrointestinal tract;

From the side of the skin:  erythema and pruritus;

Other services:  flushes of blood to the face.

Interaction

When used simultaneously, it enhances the effect of ascorbic acid on resistance and permeability of the vascular wall.

How to take, course of use and dosage

Inside while eating. Capsules are swallowed whole with a sufficient

amount of water.

At the initial stage of treatment,1 capsule (300 mg) is prescribed 2-3 times a day until the symptoms completely disappear. For maintenance treatment, the recommended dose is 1 capsule per day. The average course of treatment is 3-4 weeks. The need for longer treatment is determined individually.

In diabetic retinopathy, Troxerutin is prescribed 2 capsules (300 mg) 3 times a day (a daily dose of 18 g).

Overdose

Symptoms:  nausea headache “flushes” of blood to the face.

Treated patients:  it is necessary to wash the stomach, take activated charcoal, if necessary, start symptomatic treatment.

Special instructions

If the severity of the symptoms of the disease does not decrease during the period of using the drug, you should consult your doctor.

Experience with the use of Troxerutin in children under 18 years of age is insufficient.

Influence on the ability to drive vehicles and mechanisms:

The use of Troxerutin does not affect motor and mental reactions. The drug Troxerutin does not affect the ability to drive vehicles and work with mechanisms.

Storage conditions

Store in a dark place at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Troxerutin

Dosage form

Capsules