Unidox Solutab Dispersible pills 100mg, 20pcs

Composition

1 table.

• doxycycline monohydrate-100 mg (in terms of doxycycline)

excipients:

• MCC;
• saccharin;
• hyprolose (low-substituted);
• hypromellose;
• colloidal silicon dioxide (anhydrous);
• magnesium stearate;
• lactose monohydrate

Pharmacological action

Inhibits protein synthesis in the microbial cell, disrupting the connection of transport RNAs of the ribosomal membrane.

Pharmacokinetics

Absorption — fast and high (about 100%). Food intake does not significantly affect the absorption of the drug. Cmax of doxycycline in blood plasma (2.6-3 mcg/ml) is reached 2 hours after taking 200 mg, after 24 hours the concentration of the Active ingredient in blood plasma decreases to 1.5 mcg / ml.

After taking 200 mg on the first day of treatment and 100 mg / day on subsequent days, the concentration of doxycycline in blood plasma is 1.5-3 mcg / ml.

Distribution Doxycycline reversibly binds to plasma proteins (80-90%), penetrates well into organs and tissues, and poorly into the cerebrospinal fluid (10-20% of the blood plasma level), but the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal cord. The volume of distribution is 1.58 l / kg.

In 30-45 minutes after oral use, doxycycline is detected in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissues, pleural and ascitic fluids, bile, synovial exudate, maxillary and frontal sinus exudate, and gingival sulcus fluid. With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.

In saliva,5-27% of the concentration of doxycycline in blood plasma is determined. Doxycycline penetrates the placental barrier and is secreted in small amounts into breast milk. It accumulates in dentin and bone tissue.

Metabolism

A small part of doxycycline is metabolized. Elimination of T1 / 2 after a single oral dose is 16-18 hours, after repeated doses — 22-23 hours. Approximately 40% of the drug taken is excreted by the kidneys and 20-40% is excreted through the intestine in the form of inactive forms (chelates).

Pharmacokinetics in special clinical cases

The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestine increases. Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Pharmacodynamics

A broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S subunit of ribosomes.

Active against many gram-positive and Gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).

As a rule, it does not act on Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp. It is necessary to take into account the possibility of acquired resistance to doxycycline in a number of pathogens, which is often cross-linked within the group (i. e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Use during pregnancy and lactation

Unidox Solutab is contraindicated during pregnancy. Breast-feeding should be discontinued during treatment with Unidox.

Contraindications

• Hypersensitivity to the components of the drug Unidox Solutab, antibiotics of the tetracycline group;
• severe liver function disorders;
• severe renal function disorders;
• pregnancy and lactation;
• children under 8 years of age.

Interaction

Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by an interval of 3 hours. Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants. When doxycycline is combined with bactericidal antibiotics that disrupt cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter decreases. Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives. Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in blood plasma. Simultaneous use of doxycycline and retinol increases intracranial pressure.

Overdose

Symptoms: increased adverse reactions caused by liver damage (vomiting, fever, jaundice, azotemia, increased transaminase levels, increased PV). Treatment: immediately after taking large doses, gastric lavage, heavy drinking, and, if necessary, inducing vomiting are recommended. Prescribe activated charcoal and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficacy.

Active ingredient

Doxycycline

Conditions of release from pharmacies

By prescription

Dosage form

soluble tablets

Description

For children over 8 years of age, For adults as prescribed by a doctor, For children as prescribed by a doctor

Indications

Whooping cough, Cholecystitis, Prostatitis, Sinusitis, Pharyngitis, Urinary Tract Infections, Tracheitis, Respiratory Tract Infections, Diarrhea, Skin Infections, Female Genital inflammation, Intestinal Infections, Sore Throat, Bronchitis, Acne, Osteomyelitis, Chlamydia, Pneumonia, Urethritis, Otitis media, Sinusitis