Unithiol, ampoules 5%, 5ml, 10pcs

Composition

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1 ml of solution for intramuscular and subcutaneous use contains:

active ingredients:

sodium dimercaptopropanesulfonate monohydrate (unithiol) 50 mg;

excipients:

disodium edetate (trilon B),

0.1 M sulfuric acid (up to pH 3.1-4.5),

d/i water.

Pharmacological action

Unitiol is a complexing agent that has a detoxifying effect.

Active sulfhydryl groups of unitiol, interacting with thiol poisons (arsenic compounds, heavy metal salts) and forming non-toxic, water-soluble compounds with them, restore the functions of the body’s enzyme systems affected by the poison.

In diabetic polyneuropathy, it reduces pain, improves the condition of the peripheral nervous system, and normalizes capillary permeability.

Pharmacokinetics

Suction

When administered parenterally, it is rapidly absorbed into the blood. The maximum level of the drug in the blood (cmax ) is reached 15-30 minutes after the intravenous injection.

Deduction

The half-life (T 1/2) is 1-2 hours. It is excreted by the kidneys, mainly in the form of products of incomplete and complete oxidation, partially unchanged.

Indications

• intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides;
• hepatocerebral dystrophy (Wilson-Westphal-Konovalov disease);
• chronic alcoholism (as part of complex therapy),
• alcoholic delirium.

Contraindications

• hypersensitivity to Unitiol,
• liver failure,
• arterial hypertension.

Side effects

• nausea,
• dizziness,
• tachycardia,
• pallor of the skin,
• possible allergic reactions.

Interaction

Concomitant use of Unitiol with preparations containing heavy metals and alkalis is not recommended, as rapid decomposition of Unitiol occurs.

How to take, course of use and dosage

Unitiol is administered intramuscularly or subcutaneously.

• In case of arsenic intoxication – 5-10 ml of the drug (at the rate of 0.005 g/1 kg), on day 1 – 3-4 times, on day 2 – 2-3 times, on subsequent days-1-2 times.
• In case of poisoning with mercury compounds – according to the same scheme for 6-7 days. Treatment is carried out until the signs of intoxication disappear.
• In case of digitalis intoxication,5-10 ml of a 5% aqueous solution is administered 3-4 times/day in the first 2 days, then 1-2 times / day until the cardiotoxic effect ceases.
• With hepatocerebral dystrophy – in / m 5-10 ml of a 5% solution daily or every other day; the course of treatment is 25-30 injections; if necessary, repeat after 3-4 months.
• For chronic alcoholism,3-5 ml is prescribed 2-3 times a week.
• To stop delirium – once 4-5 ml.

Overdose

Symptoms:  shortness of breath, hyperkinesis, lethargy, lethargy, deafness, short-term convulsions (occur when the recommended therapeutic dose is exceeded by more than 10 times).

Treatment:  symptomatic therapy.

Special instructions

In case of acute poisoning, additional therapeutic measures are carried out (gastric lavage, oxygen therapy, dextrose use, etc. ).

Form of production

Solution for intramuscular and subcutaneous use.

Storage conditions

Store in a dark place at a temperature of 0 to 25 °C. Do not freeze it.

Shelf

life is 5 years.

Active ingredient

Sodium Dimercaptopropanesulfonate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

For adults as directed by your doctor

Indications

Alcoholism, Polyneuropathy