Vancorus lyophilisate for infusion solution 0.5g vial 1pc

Composition

1 bottle contains vancomycin (in the form of hydrochloride) 0.5 g

Pharmacological action

An antibiotic of the glycopeptide group.

Vancomycin has a bactericidal effect.

Disrupts cell wall synthesis, cytoplasmic membrane permeability, and bacterial RNA synthesis.

Active against gram-positive bacteria: Staphylococcus spp. (including penicillinase-producing and methicillin-resistant strains), Streptococcus spp., Enterococcus spp., Corynebacterium spp., Listeria spp., Actinomyces spp., Clostridium spp. (including Clostridium difficile). There was no cross-resistance with other groups of antibiotics.

Indications

Severe infectious and inflammatory diseases caused by vancomycin-sensitive pathogens (if penicillins and cephalosporins are ineffective or intolerant): sepsis, endocarditis, pneumonia, lung abscess, meningitis, osteomyelitis. Pseudomembranous colitis caused by Clostridium difficile.

Use during pregnancy and lactation

Use in the first trimester of pregnancy is contraindicated due to the risk of nephrotoxicity and ototoxicity.

The use of vancomycin in the second and third trimesters is possible only for vital indications.

If necessary, use during lactation, breastfeeding should be discontinued.

Contraindications

Neuritis of the auditory nerve, I trimester of pregnancy, severe renal dysfunction, hypersensitivity to vancomycin.

Side effects

With rapid intravenous use, “red neck syndrome” associated with histamine release may develop: erythema, skin rash, redness of the face, neck, upper body, hands, rapid heartbeat, nausea, vomiting, chills, fever, fainting.

From the urinary system:  urination disorders, interstitial nephritis.

From the central nervous system:  hearing loss, ringing and a feeling of “laying” in the ears.

From the hematopoietic system:  neutropenia, eosinophilia, thrombocytopenia, agranulocytosis.

Allergic reactions:  pruritus, urticaria, anaphylactic reactions.

Interaction

When administered concomitantly with local anesthetics, children may develop erythematous rashes and hyperemia of the skin of the face, while adults may have a violation of intracardiac conduction.

Concomitant use with nephrotoxic and ototoxic drugs (aminoglycosides, amphotericin B, ASA or other salicylates, bacitracin, bumetanide, capreomycin, carmustine, paromomycin, cyclosporine, loop diuretics, polymyxin B, cisplatin, etacric acid) is not recommended. Colestyramine reduces its effectiveness.

Antihistamines, meclozin, phenothiazines, and thioxanthenes can mask symptoms of the ototoxic effect of vancomycin (tinnitus, vertigo). General anesthetics and vecuronium bromide – risk of lowering blood pressure or developing neuromuscular blockade. Infusion of vancomycin is possible at least 60 minutes before their introduction.

How to take, course of use and dosage

Enter IV drip. Adults – 500 mg every 6 hours or 1 g every 12 hours. To avoid collaptoid reactions, the duration of the infusion should be at least 60 minutes.

Children – 40 mg / kg / day, each dose should be administered for at least 60 minutes. In patients with impaired excretory function of the kidneys, the dose is reduced taking into account the values of creatinine clearance. Depending on the etiology of the disease, Vancomycin can be taken orally. For adults, the daily dose is 0.5-2 g in 3-4 doses, for children-40 mg / kg in 3-4 doses.

The maximum daily dose for adults with intravenous use is 3-4 g.

Overdose

Symptoms:  increased severity of side effects.

Treatment:  symptomatic in combination with hemoperfusion and hemofiltration.

Special instructions

Use in the II-III trimester of pregnancy is possible only for “vital” indications. When prescribing to preterm and normal newborns, monitoring of serum concentrations is desirable.

Concomitant use with general anesthetics increases the frequency of side effects, so it is better to administer vancomycin before general anesthesia. During treatment, it is necessary to conduct an audiogram, determine kidney function (urinalysis, creatinine and urea nitrogen).

It is advisable to determine the concentration of vancomycin in the blood serum (in patients with renal insufficiency, in patients older than 60 years). Maximum concentrations should not exceed 40 micrograms/ml, and minimum concentrations should not exceed 10 micrograms / ml. Concentrations above 80 micrograms / ml are considered toxic

Product form

powder for preparation of solution for infusions

Storage conditions

At a temperature of 15-30 °C.

Shelf

life is 2 years.

Active ingredient

Vancomycin

Conditions of release from pharmacies

By prescription

Dosage form

solution for infusions

Description

For adults as prescribed by a doctor, for children as prescribed by a doctor

Indications

From pneumonia, From infectious diseases, From osteomyelitis