Vasoket pills 600mg, 30pcs

Composition

Active ingredient:

diosmin 600 mg.

Excipients: povidone, microcrystalline cellulose, corn starch, magnesium stearate.

Pharmacological action

Pharmacotherapeutic group: venotonizing and venoprotective agent.

ATX Code: [C05CA03]

Pharmacological properties

Pharmacodynamics

Diosmin has a venotonizing effect (reduces the extensibility of veins, increases the tone of veins (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to the paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, has an anti-inflammatory effect. Increases the vasoconstrictor effect of epinephrine, norepinephrine, serotonin, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane..

Pharmacokinetics

After oral use, the drug is rapidly absorbed from the gastrointestinal tract and is detected in blood plasma after 2 hours. The maximum concentration in the blood plasma is reached 5 hours after use. It is evenly distributed and accumulates in all layers of the wall of the vena cava and subcutaneous veins of the lower extremities, to a lesser extent-in the kidneys, liver, lungs and other organs. Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. Diosmin is excreted by the kidneys 79%, intestines-11%, with bile-2.4%.

Indications

Varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower extremities; exacerbation of hemorrhoids; microcirculation disorders.

Use during pregnancy and lactation

So far, no side effects have been reported in clinical practice when using the drug in pregnant women. In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, since there are no data on the penetration of the drug into breast milk.

Contraindications

Hypersensitivity to the components of the drug, children (under 18 years of age).

Side effects

In rare cases, from the gastrointestinal tract-dyspeptic disorders.

From the central nervous system – headache.

Interaction

Clinically significant interaction effects with other drugs have not been described.

How to take, course of use and dosage

With varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in the legs),1 tablet is prescribed per day in the morning before breakfast for 2 months, with severe forms of chronic lymphovenous insufficiency (edema, pain, convulsions, etc. ) – treatment is continued for 3-4 months, in the presence of trophic changes and ulcers, treatment is extended to 6 months or more. The course is repeated in 2-3 months.

In case of exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets a day with meals for 7 days, then, if necessary, you can continue 1 tablet 1 time a day for 1-2 months.

In the treatment of chronic lymphovenous insufficiency during the II and III trimester of pregnancy,1 tablet is prescribed 1 time a day and canceled 2-3 weeks before delivery.

If you have missed one or more meals, continue using the drug in the usual dosage.

Overdose

Overdose symptoms are not described.

Description

Oblong tablets from grayish-yellow to light yellow in color with a fault line on both sides.

Special instructions

Treatment of acute hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy.

There are data on the possible effectiveness of the drug in the treatment of fetoplacental insufficiency, for the prevention of bleeding that occurs during the use of intrauterine devices and during phlebectomy.

Storage conditions

Store at a temperature not exceeding 30 °C.

Keep out of the reach of children.

Shelf life

3 years

Do not use after the expiration date indicated on the package.

Active ingredient

Diosmin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, for pregnant women as prescribed by a doctor

Indications

Hemorrhoids, Varicose Veins