Vectibix concentrate 20mg/ml 5ml, 1pc

Vectibix: What is it?

What is Vectibix?

Vectibix is a medication whose active ingredient is panitumumab. This human monoclonal antibody targets and blocks the epidermal growth factor receptor (EGFR), a protein crucial for the development and spread of certain cancer cells. Vectibix is prescribed for patients with wild-type RAS mutation in metastatic colorectal cancer (mCRC).

Vectibix Compositions

Vectibix Composition

Vectibix concentrate contains 20 mg of panitumumab per milliliter. It comes in 5 mL vials containing 100 mg of panitumumab. Vectibix is a colorless liquid, possibly with visible particles.

Vectibix: Benefits and Effects

Benefits and Effects of Vectibix

Vectibix blocks the EGFR, slowing down the spread and growth of cancer cells. This can lead to tumor shrinkage and improved overall survival.

What is Vectibix Used For?

Vectibix Uses

Vectibix is indicated for patients with wild-type RAS metastatic colorectal cancer (mCRC). This means the RAS gene in the cancer cells has not undergone mutations.

How to Use Vectibix

Vectibix Administration

Vectibix is administered intravenously—into a vein—using an infusion pump. The prescribed dosage is 6 mg/kg (milligrams per kilogram of body weight) once every two weeks. The infusion typically lasts for sixty minutes.

Vectibix Dosage and Administration

Vectibix Dosage

The recommended dosage of Vectibix is 6 mg/kg, given intravenously over 60 minutes, every 14 days. If the initial infusion is well-tolerated, subsequent infusions may be given over 30 to 60 minutes. Dosages higher than 1000 mg should be administered over 90 minutes.

Vectibix Side Effects

Common Side Effects of Vectibix

The most common side effects of Vectibix include skin rash, paronychia, tiredness, nausea, and diarrhea. Other possible side effects include:

• Infusion reactions
• Dermatological harm
• Electrolyte depletion
• Lung fibrosis
• Ocular toxicity
• Embryo-fetal toxicity

Vectibix Contraindications

Contraindications for Vectibix

Vectibix should be avoided by patients with known hypersensitivity to panitumumab or any of the excipients. Patients with RAS-mutant mCRC also have contraindications.

Important Considerations Following Vectibix Treatment

Important Considerations

• Before starting Vectibix treatment, it is crucial to determine the RAS mutational status in colorectal cancers to ensure the patient has wild-type RAS mCRC.
• Appropriate medical resources should be readily available for the treatment of severe infusion reactions.
• Patients should be advised to limit sun exposure, drink plenty of fluids, and apply sunscreen with an SPF of 15 or higher.
• Patients should be monitored for potential side effects, and appropriate dose adjustments should be made as needed.

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