Ventolin, inhalation aerosol 100 µg/dose, 200 doses

Composition

1 dose contains 100 mcg of salbutamol (in the form of salbutamol sulfate).

Pharmacological action

Salbutamol is a selective agonist of b2-adrenergic receptors.

In therapeutic doses, it acts on the b2-adrenoreceptors of the smooth muscles of the bronchi, having little or no effect on the b1-adrenoreceptors of the myocardium.

Indications

Bronchial asthma

– relief of attacks of bronchial asthma, including in case of exacerbation of severe bronchial asthma; – prevention of attacks of bronchospasm associated with exposure to an allergen or caused by physical exertion;- use as one of the components in long-term maintenance therapy of bronchial asthma.

Chronic obstructive pulmonary disease (COPD), accompanied by reversible airway obstruction, including chronic bronchitis and emphysema.

Use during pregnancy and lactation

During lactation and pregnancy, the drug is prescribed only in cases where the expected benefit to the mother exceeds any possible risk to the fetus.

Salbutamol probably passes into breast milk, so nursing women are advised not to take it unless the expected benefit to the mother outweighs any potential risk to the baby.

It is not known whether salbutamol present in breast milk has any negative effect on the newborn baby.

Contraindications

-Threatening abortion.

– Hypersensitivity to any component of the drug.

– Management of preterm labor.

– Children under 2 years of age.

Side effects

Salbutamol can cause mild skeletal muscle tremor, which is usually most pronounced in the hands and is a characteristic side effect of all b2-adrenergic agonists. Occasionally, patients have a headache, dilated peripheral blood vessels, and a slight compensatory increase in heart rate.

Hypersensitivity reactions (including angioedema, urticaria, bronchospasm, hypotension and collapse), muscle cramps, and tachycardia are very rare.

Inhaled medications can cause paradoxical bronchospasm. Paradoxical bronchospasm should be immediately stopped with another dosage form of salbutamol or another fast-acting inhaled bronchodilator. You should immediately stop using the Ventolin inhaler, assess the patient’s condition, conduct the necessary examination and prescribe appropriate therapy. Inhaled medications can cause irritation of the oral and pharyngeal mucosa.

Beta-2-adrenergic agonist therapy sometimes causes hypokalemia, which can pose a serious risk to the patient. Like other beta-2-adrenergic agonists, salbutamol may occasionally cause mental arousal and increased motor activity in children.

In patients predisposed to developing arrhythmias, salbutamol may cause cardiac arrhythmias, including atrial fibrillation, supraventricular tachycardia, and extrasystole.

Interaction

It is not recommended to use salbutamol and non-selective b-adrenergic blockers, such as propranolol, at the same time.

Salbutamol is not contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs).

How to take, course of use and dosage

Ventolin metered-dose aerosol is intended for inhalation use only.

Only a doctor can decide whether to increase the dose or frequency of use of the drug.

It is not recommended to use the Ventolin inhaler more than 4 times a day. The need for frequent use of maximum doses of Ventolin or a sudden increase in the dose indicates a worsening of the course of the disease.

Adults (including elderly patients)

Relief of an attack of bronchospasm:  the recommended dose is 100-200 mcg (1-2 inhalations).

Prevention of bronchospasm attacks associated with allergen exposure or caused by physical exertion: the recommended dose is 200 mcg (2 inhalations) 10-15 minutes before exposure to the provoking factor.

Long-term maintenance therapy:  the recommended dose is up to 200 mcg (2 inhalations) 4 times a day. Ventolin can be administered via the Volumatic spacer.

Children

Relief of an attack of bronchospasm:  the recommended dose is 100-200 mcg (1-2 inhalations).

Prevention of bronchospasm attacks associated with allergen exposure or caused by physical exertion: the recommended dose is 100-200 mcg (1-2 inhalations) 10-15 minutes before exposure to the provoking factor.

Long-term maintenance therapy:  the recommended dose is up to 200 mcg (2 inhalations) 4 times a day. Ventolin can be administered via the spacer ‘Babyhaler’ or ‘Volumatic’.

Overdose

In case of salbutamol overdose, the best antidotes are cardioselective b-blockers.

However, b-blockers should be used with caution in patients with a history of bronchospasm attacks.

The use of high doses of salbutamol can cause hypokalemia, so if an overdose is suspected, the level of potassium in the blood serum should be monitored.

Special instructions

Salbutamol should be used with caution in patients with thyrotoxicosis. Therapy with b2-adrenergic agonists, especially when administered parenterally or with a nebulizer, can lead to hypokalemia.

Special care should be taken in the treatment of severe asthma attacks, since in these cases hypokalemia may increase as a result of simultaneous use of xanthine derivatives, glucocorticosteroids, diuretics, as well as due to hypoxia. In such situations, it is necessary to monitor the level of potassium in the blood serum.

Patients should be instructed about the correct use of the Ventolin inhaler. Bronchodilators should not be the only or main component of treatment for unstable or severe asthma.

If the effect of the usual dose of Ventolin becomes less effective or less prolonged (the effect of the drug should last at least 3 hours), the patient should consult a doctor.

An increased need for short-acting inhaled b2-adrenergic agonists to control the symptoms of bronchial asthma indicates an exacerbation of the disease. In such cases, the patient’s treatment plan should be reviewed.

Sudden and progressive deterioration of bronchial asthma can pose a threat to the patient’s life, so in such situations, it is necessary to urgently decide whether to prescribe or increase the dose of glucocorticosteroids. In such patients, it is recommended to monitor the peak expiratory rate daily.

Very high doses of salbutamol can lead to the development of adverse reactions, so only a doctor can decide whether to increase the dose or frequency of use of the drug.

Patients using Ventolin Nebula at home should be warned that if the effect of the usual dose becomes less effective or less prolonged, you can not independently increase the dose or frequency of use of the drug, but you should immediately consult a doctor.

Ventolin Nebula should be used with caution in patients who have already taken high doses of other sympathomimetics.

Form of production

Metered-dose aerosol for inhalation.

Storage conditions

In a dark place, at a temperature not exceeding 30 °C (do not freeze or heat)

Shelf life

2 years

Active ingredient

Salbutamol

Conditions of release from pharmacies

By prescription

Dosage form

aerosol for inhalation

Description

For adults as prescribed by a doctor, Children as prescribed by a doctor, Children over 2 years of age, Nursing mothers as prescribed by a doctor

Indications

Bronchospasm, Chronic Obstructive pulmonary disease, Bronchial asthma