Viagra, pills 50mg, 1pc

Composition

Active ingredient:

sildenafil (as sildenafil citrate) 50 mg;

other nutrients:

microcrystalline cellulose,

calcium hydrophosphate (anhydrous),

sodium croscarmellose,

magnesium stearate,

Opadry blue and Opadry transparent film coating.

Pharmacological action

VIAGRA is a drug for the treatment of erectile dysfunction (erectile dysfunction). It acts on the natural mechanisms of erection. It is used in men suffering from erectile dysfunction of various origins (vascular, nervous erectile disorders).

Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate( cGMP), relaxation of the smooth muscles of the cavernous body, and increased blood flow to the penis.

Sildenafil does not have a direct relaxing effect on the isolated human cavernous body, but actively enhances the relaxing effect of NO on this tissue by inhibiting PDE5, which is responsible for the breakdown of cGMP in the cavernous body.

During sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in cGMP levels in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body.

A prerequisite for the effectiveness of sildenafil is sexual stimulation.

Indications

Treatment of erectile dysfunction characterized by the inability to achieve or maintain a penile erection sufficient for satisfactory sexual intercourse.

Viagra is effective only when sexual stimulation is present.

Contraindications

-Hypersensitivity to any component of the drug. – Use in patients receiving continuous or intermittent nitric oxide donors, organic nitrates or nitrites in any form. – Under 18 years of age. – Not intended for use in women.

With caution:  anatomical deformity of the penis (incl. angulation, cavernous fibrosis, or Peyronne’s disease), diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma. leukemia, thrombocythemia), diseases accompanied by bleeding, exacerbation of peptic ulcer disease, hereditary retinitis pigmentosa, heart failure, unstable angina, myocardial infarction, stroke or life-threatening arrhythmias in the last 6 months, arterial hypertension (BP > 170/100 mm Hg) or hypotension (BP >

Side effects

Adverse events are usually transient and mild to moderate. The frequency of adverse events increases with increasing dose.

From the body as a whole:  asthenia, aches, abdominal pain, back pain, infection, flu-like syndrome.

From the cardiovascular system:  vasodilation (a side effect reported in clinical trials).

From the digestive system:  diarrhea, nausea.

Musculoskeletal disorders:  joint pain, muscle pain.

From the central nervous system and peripheral nervous system: dizziness (side effect reported in clinical studies), increased muscle tone, insomnia.

Respiratory system disorders:  nasal congestion, pharyngitis, rhinitis (a side effect reported in clinical studies), sinusitis, respiratory tract infections, respiratory dysfunction.

Dermatological reactions:  a rash.

From the side of the senses:  visual changes: mild and transient, mainly changes in the color of objects, as well as increased light perception and blurred vision (a side effect reported in clinical studies), conjunctivitis.

From the urinary system:  urinary tract infections.

From the side of the reproductive system:  impaired prostate function.

When using the drug in doses higher than recommended, side effects were similar to those noted above, but usually occurred more frequently.

The following lists the adverse events reported during the post-marketing application process.

From the cardiovascular system:  hypotension, syncope, tachycardia, palpitations.

From the digestive system:  vomiting (side effect reported in clinical trials). From the side of the reproductive system:  prolonged erections and / or priapism. From the side of the senses:  pain in the eyes, redness of the eyes. Other services:  allergic reactions.

How to take, course of use and dosage

The drug is taken orally. For most patients, the recommended dose is 50 mg; the drug is taken if necessary approximately 1 hour before sexual activity. Depending on the efficacy and tolerability, the dose can be increased to 100 mg or reduced to 25 mg.

The maximum recommended dose is 100 mg. The maximum recommended frequency of application is 1 time/day.

Special instructions

To diagnose erectile dysfunction, determine their possible causes, and choose appropriate treatment, it is necessary to collect a complete medical history and conduct a thorough physical examination.

Treatment of erectile dysfunction should be used with caution in patients with anatomical deformity of the penis (angulation, cavernous fibrosis, Peyronie’s disease), or in patients with risk factors for priapism (sickle cell anemia, multiple myeloma, leukemia).

Drugs intended for the treatment of erectile dysfunction should not be prescribed to men for whom sexual activity is undesirable.

Form of production

Coated tablets.

Storage conditions

At a temperature not exceeding 30 °C

Shelf life

4 years

Active ingredient

Sildenafil

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as prescribed by a doctor, For men

Indications

Erectile Dysfunction