Wilprafen granules for oral suspension preparation 250mg/5ml, 15g

Composition

>of 1 fl contains: josamycin propionate-3.1545 g

Pharmacological action

An antibiotic of the macrolide group. It has a bacteriostatic effect due to inhibition of protein synthesis by bacteria. When creating high concentrations in the focus of inflammation, it has a bactericidal effect.

Highly active against intracellular microorganisms: Chlamydia trachomatis and Chlamydia pneumonuae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila; against gram-positive aerobic bacteria: Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphtheriae; gram-negative aerobic bacteria: Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis; against some anaerobic bacteria: Peptococcus, Peptostreptococcus, Clostridium perfringens.

Josamycin is also active against Treponema pallidum.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to josamycin: upper respiratory tract and ENT infections (including pharyngitis, tonsillitis, paratonsillitis, otitis media, sinusitis, laryngitis); diphtheria (in addition to treatment with diphtheria antitoxin); scarlet fever (with hypersensitivity to penicillin); lower respiratory tract infections (including acute bronchitis, bronchopneumonia, pneumonia, including atypical form, whooping cough, psittacosis); oral infections (including gingivitis and periodontal diseases); skin and soft tissue infections (including pyoderma, boils, anthrax, erysipelas /with hypersensitivity to penicillin/, acne, lymphangitis, lymphadenitis); urinary tract and genital infections (including urethritis, prostatitis, gonorrhea; with hypersensitivity to penicillin). penicillin-syphilis, venereal lymphogranuloma); chlamydia, mycoplasma (including ureaplasma) and mixed urinary tract infections When taken orally for adults and children over 14 years of age-1-2 g/day in 2-3 doses. Children under 14 years of age – 30-50 mg / kg / day in 3 divided doses. The duration of treatment depends on the indications for use. their pathways and genitals.

Contraindications

Severe hepatic impairment, hypersensitivity to erythromycin and other macrolide antibiotics.

Side effects

From the digestive system:  rarely-lack of appetite, nausea, heartburn, vomiting, diarrhea, pseudomembranous colitis;

in some cases-increased activity of hepatic transaminases, impaired bile outflow and jaundice.

Allergic reactions:  rarely – urticaria.

Other services:  in some cases, there are dose – dependent transient hearing disorders.

Interaction

Bacteriostatic antibiotics may reduce the bactericidal effect of other antibiotics, such as penicillins and cephalosporins (concomitant use of josamycin with penicillins and cephalosporins should be avoided).

Concomitant use of josamycin with lincomycin may reduce the effectiveness of both drugs.

Josamycin slows down the elimination of theophylline to a lesser extent than other macrolide antibiotics.

Josamycin slows down the elimination of terfenadine or astemizole, which increases the risk of life-threatening arrhythmias.

There are separate reports of increased vasoconstrictor effect with simultaneous use of macrolide antibiotics and ergot alkaloids. There was 1 case of ergotamine intolerance when taking josamycin.

Concomitant use of josamycin and cyclosporine may increase the concentration of cyclosporine in blood plasma up to nephrotoxic.

Concomitant use of josamycin and digoxin may increase the level of the latter in blood plasma.

In rare cases, during treatment with macrolides, the contraceptive effect of hormonal contraceptives may be insufficient.

How to take, course of use and dosage

When taken orally, adults and children over 14 years of age – 1-2 g / day in 2-3 doses. Children under 14 years of age – 30-50 mg / kg / day in 3 divided doses. The duration of treatment depends on the indications for use.

Special instructions

If pseudomembranous colitis develops, josamycin should be discontinued and appropriate therapy should be prescribed. Medications that reduce intestinal motility are contraindicated.

In patients with renal insufficiency, dosage adjustment is required in accordance with the values of creatinine clearance.

Josamycin is not prescribed for premature babies. When used in newborns, liver function should be monitored.

Consideration should be given to the possibility of cross-resistance to various macrolide antibiotics (for example, microorganisms resistant to treatment with chemically related antibiotics may also be resistant to josamycin).

Active ingredient

Josamycin

Conditions of release from pharmacies

By prescription

Dosage form

suspension for external use