ATC code | A10BD07 |
---|---|
CAS Number | 154270-90-3 (dapagliflozin) |
Other product names | Xigduo XR, Dapagliflozin/Metformin |
Dosage form | Tablet, extended release |
Active ingredient | Dapagliflozin and metformin hydrochloride |
Other ingredients | Hypromellose, microcrystalline cellulose, croscarmellose sodium, titanium dioxide, magnesium stearate, stearic acid, FD&C yellow 5, FD&C blue 1, propylene glycol, triacetin, stearic acid, acacia gum, maltodextrin, Iron oxides |
Pharmacological classification | Antidiabetics, biguanides, SGLT2 inhibitors |
Pharmacological action | Lowers blood sugar levels, helps lower the risk for related health conditions, such as worsening heart failure or chronic kidney disease (CKD) |
Storage conditions | Store at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. |
Xigduo XR: A Comprehensive Guide for Type 2 Diabetes Management
Xigduo XR is a medication used by adults with type 2 diabetes to manage their condition. It combines two medications: metformin and dapagliflozin, to help lower blood sugar levels. This combination is particularly effective in patients whose glycemic control is insufficient with diet and exercise alone.
Compositional Structure of Xigduo XR
Xigduo XR tablets consist of:
- Metformin hydrochloride (HCl), a biguanide
- Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor
Dapagliflozin helps the kidneys remove excess sugar from your blood through urine. Metformin lowers the sugar your liver produces and improves your bodys use of insulin.
Benefits and Effects of Xigduo XR
Using Xigduo XR can offer several health benefits, including:
- Better glycemic control: Metformin and dapagliflozin work together to reduce blood sugar levels and improve overall glycemic control.
- Lowered risk of heart failure: Studies suggest that SGLT2 inhibitors like dapagliflozin can reduce the risk of heart failure in individuals with type 2 diabetes.
- Lowered risk of renal disease: Metformin has been shown to slow the progression of kidney disease in individuals with type 2 diabetes.
- Potential for weight loss: Dapagliflozin may encourage minor weight loss in some individuals.
Xigduo XR is primarily used for the treatment of type 2 diabetes. It is typically recommended in combination with diet and exercise and is advised when other medications are unable to adequately control blood sugar levels.
How to Use Xigduo XR
Xigduo XR tablets are taken orally once a day with food. Your doctor will determine the appropriate dosage based on your individual needs and response to the medication. Always use Xigduo XR as directed and never adjust the dosage without consulting your doctor.
Dosage and Administration of Xigduo XR
The recommended starting dosage of Xigduo XR is one tablet containing 10 mg of dapagliflozin and 1000 mg of metformin hydrochloride once daily. Your doctor may adjust the dosage depending on your specific requirements and response to the medication.
Potential Side Effects of Xigduo XR
Like all medications, Xigduo XR can cause side effects, although not everyone experiences them. Common side effects include:
- Nausea
- Diarrhea
- Constipation
- Loss of appetite
- Genital yeast infections, particularly in women
Although rare, some serious adverse effects are possible. These include:
- Lactic acidosis (a buildup of lactic acid in the blood)
- Low blood sugar (hypoglycemia)
- Vitamin B12 deficiency
- Kidney problems
- Bladder cancer
If you experience any unusual or severe side effects, consult your doctor immediately.
Contraindications for Xigduo XR
Xigduo XR is not suitable for everyone. It should not be used by individuals with the following conditions:
- Severe renal disease (estimated glomerular filtration rate less than 30 mL/min/1.73 m2)
- Advanced liver disease
- Diabetic ketoacidosis (a major complication of diabetes)
- Severe heart failure
- Allergies to metformin, dapagliflozin, or any other component of Xigduo XR
Before starting Xigduo XR, ensure your doctor is aware of any allergies, medical conditions, or medications you are currently taking.
Storage Conditions of Xigduo XR
Store Xigduo XR tablets at room temperature, away from heat, light, and moisture. Keep them out of reach of pets and children.
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