Xilen nasal spray 0.1%, 15ml

Composition

Active ingredient: Xylometazoline Hydrochloride 1.0 mgm Auxiliary substances: Benzalkonium chloride in terms of anhydrous 0.15 mg Disodium edetate dihydrate 0.5 mg Potassium dihydrogen phosphate 3.63 mgSodium hydrophosphate dodecahydrate 7.13 mgSodium chloride 9.0 mg water purified to 1.0 ml

Pharmacological action

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity. The drug facilitates nasal 2 breathing by reducing swelling and hyperemia of the mucous membrane, and also improves the discharge of secretions. The effect of the drug occurs a few minutes after its use and lasts up to 10 hours.

Indications

Acute respiratory diseases with rhinitis (runny nose), acute allergic rhinitis, sinusitis, otitis media (as part of combination therapy to reduce nasopharyngeal mucosal edema), pollinosis, eustachiitis, to facilitate rhinoscopy.

Recommendations for use

Intranasally. Before use, it is necessary to clean the nasal passages. Adults and children over 6 years of age: 1 injection of 0.1% xylometazoline solution in each nasal passage 2-3 times a day. Do not use for more than 5-7 days, as xylometazoline can cause swelling of the nasal mucosa, leading to its atrophy. Children aged 2 to 6 years apply 0.05% xylometazoline solution 1 injection in each nasal passage 1-2 times a day. Do not use the drug more than 3 times a day. The duration of use of the drug udetey is determined by the doctor.

Contraindications

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the meninges (in the anamnesis), children under 2 years of age-for 0.05% solution (0.0005 g/ml), children under 6 years of age – for 0.1% solution (0.001 g/ml), thyrotoxicosis, conditions after transsphenoidal pituitary surgery, pregnancy. Do not use with monoamine oxidase inhibitors and tricyclic antidepressants (including a period of 14 days after their withdrawal), as well as with other drugs that increase blood pressure. Use caution during breastfeeding, coronary heart disease (angina pectoris), diabetes mellitus, prostatic hyperplasia, hyperthyroidism, porphyria, pheochromocytoma, patients with hypersensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Side effects

With frequent and/or prolonged use – irritation and/or dryness of the nasopharyngeal mucosa, burning, paresthesia, sneezing, hypersecretion; rarely – swelling of the nasal mucosa, nosebleeds, palpitations, tachycardia, arrhythmia, increased blood pressure, nausea, vomiting, headache, insomnia, visual impairment, depression (with prolonged use of high doses), anxiety, fatigue, hallucinations and convulsions (mainly in children), hypersensitivity reactions (angioedema, skin rash, pruritus). Benzalkonium chloride, which is part of the drug, can cause irritation and swelling of the nasal mucosa.

Interaction

Concomitant use of xylometazoline with monoamine oxidase inhibitors (MAOIs)and tricyclic antidepressants may lead to increased arterial pressure.

Overdose

Symptoms: in case of overdose or accidental ingestion of the drug, the following symptoms may develop: nausea, vomiting, cyanosis, fever, a significant decrease in body temperature, shortness of breath, dizziness, increased sweating, headache, bradycardia, arrhythmia, tachycardia, increased blood pressure, followed by a decrease in blood pressure, respiratory depression, coma, convulsions. Young children with overdose often have dominant central effects with seizures, coma and bradycardia, apnea, and an increase in blood pressure that follows hypotension. Treatment:  symptomatic under the supervision of a doctor. The patient should be monitored for several hours. In case of accidental ingestion-gastric lavage, taking activated charcoal.

Special instructions

Prolonged use (more than 7 days) can lead to reactive hyperemia of the nasal mucosa and atrophy of the nasal mucosa. Do not exceed the recommended dosage. Benzalkonium chloride, which is part of the drug, can cause irritation and swelling of the nasal mucosa. It is not recommended to use the drug continuously for more than 7 days. Avoid getting the drug in your eyes

Storage conditions

At a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf

life is 3 years. Do not use after the expiration date indicated on the package

Active ingredient

Xylometazoline

Dosage Form

Spray nasal