Zyprexa, pills 10mg, 28pcs

Composition

Active ingredient:

olanzapine 10 mg

The pharmacological effect

of Ziprex is antipsychotic.

Being a ligand of serotonin (2A/2C,3,6), dopamine (_D1–_D5), m-choline (_{m1 – m5}), histamine_H1-and alpha_{– 1}-adrenergic receptors, it selectively affects the limbic system.

Pharmacokinetics

Well absorbed, _cmax in plasma-after 5-8 hours. It is metabolized in the liver (via conjugation and oxidative pathways) to inactive metabolites. The main metabolite,10-N-glucuronide, does not pass through the BBB. The average T_1/2 varies (depending on age and gender) in the range of 21-54 hours.

Indications

Acute form of schizophrenia, etc. psychoses, accompanied by pronounced positive (delusions, hallucinations, thinking disorders, hostility, suspicion) and/or negative (blunted affect, emotional and social isolation, poor speech activity) symptoms.

Secondary affective symptoms on the background of schizophrenia and concomitant disorders.

Use during pregnancy and lactation

Ziprexa is contraindicated in pregnancy, lactation and children under 18 years of age.

Contraindications

Hypersensitivity

Side effects

are frequent-drowsiness, weight gain;

rare-dizziness, dry mouth, constipation, peripheral edema, orthostatic hypotension, akathisia, dystonia, eosinophilia (asymptomatic), a small and temporary increase in prolactin levels (gynecomastia, lactorrhea), liver transaminase activity.

Interaction

Reduces the effects of levodopa and dopamine agonists.

Activated charcoal reduces bioavailability by 50-60% when taken orally.

Smoking and carbamazepine boost your metabolism.

There was no obvious interaction with antacids, cimetidine, imipramine, warfarin, diazepam, lithium, theophylline, and biperiden.

How to take, course of use and dosage

Inside, regardless of food intake.

The initial dose is from 10 mg / day, once.

Then the daily dose may vary from 5 to 20 mg / day, depending on the clinical condition.

Overdose

Symptoms:  nausea, confused speech, drowsiness.

Mydriasis, respiratory depression, hypotension, and extrapyramidal disorders were observed in animal experiments.

Treatment:  there is no specific antidote.

Treatment is symptomatic, with the obligatory use of activated carbon, providing good ventilation and oxygen saturation;

in case of collapse, intravenous use of norepinephrine (but not adrenomimetics with beta-stimulating activity-epinephrine, dopamine, etc. ).

Tablet Form of production

Storage conditions

Store in a dry place, protected from light, at a temperature of 15-30 °C

Shelf life

3 years

Active ingredient

Olanzapine

Conditions of release from pharmacies

By prescription

Dosage form

Tablets