Bacteriophage Klebsiella polyvalent, vials, 20ml, 4pcs

Composition

The solution contains:

Active ingredient:

sterile mixture of purified Klebsiella pneumonia,

Klebsiella ozaenae,

Klebsiella rhinoscleromatis phagolysate filtrates 10 ml.

Auxiliary substances:

8-hydroxyquinoline sulfate monohydrate 0.0001 g / ml.

Pharmacological action

The drug causes specific lysis of the bacteria Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.

Indications

Treatment and prevention of diseases caused by Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis bacteria as part of complex therapy:

• ozena, a scleroma;
• diseases of the gastrointestinal tract (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbiosis);
• inflammatory diseases of newborns and children of early age (gastroenterocolitis, intestinal dysbiosis, omphalitis, pemphigus, pyoderma, septicaemia and pyosepticemia of various localization);
• surgical infections (wounds, abscesses, purulent skin lesions, burns, peritonitis, pleurisy, mastitis, osteomyelitis, abscess);
• urogenital infections (cystitis, pyelonephritis, urethritis, endometritis, vulvitis, bartholinitis, obesity, oophoritis);
• purulent-inflammatory diseases of the ear, throat, nose, sinuses, oral cavity, pharynx, larynx, bronchi, lungs and pleura (otitis, tonsillitis, pharyngitis, laryngitis, stomatitis, periodontitis, sinusitis, frontal sinusitis, bronchitis, pneumonia, pleurisy);
• post-traumatic conjunctivitis, keratoconjunctivitis, purulent ulcer of the cornea and iridocyclitis;
• prevention of nosocomial infections caused by Klebsiella.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Allergic reactions.

How to take, course of use and dosage

The drug is used for oral use( through the mouth), in the form of enemas, applications, irrigation, introduction into the cavities of wounds, vagina, uterus, nose, sinuses, as well as in drained cavities: abscesses, abdominal, pleural, bladder, renal pelvis.

Inside, the drug is taken on an empty stomach 0.5-1 hour before meals.

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally.

If the purulent focus cavity is treated with chemical antiseptics, it should be washed with a sterile 0.9% sodium chloride solution before using the bacteriophage.

In the treatment of ozena and scleroma, the drug is used for washing the nasal cavity and mucous membrane of the upper respiratory tract, for introduction into the sinus cavities (for clinical indications), as well as for damage to the pharynx, larynx, trachea in the form of inhalations (without heating and using ultrasound).

The dose of the drug for the treatment of nasal and upper respiratory tract mucosa is 10-20 ml. After washing the mucous membranes in the nasal cavity, turunds moistened with the drug are introduced into each nasal passage in turn and left for 1 hour. The procedure is repeated 2-3 times a day for 20-40 days. Since ozena and scleroma are chronic diseases, in order to prevent exacerbations, it is recommended to conduct 20-40 day courses of treatment once a year according to the above scheme.

In the treatment of angina, pharyngitis, laryngitis, the drug is used for rinsing the mouth and throat 3 times a day for 10-20 ml, the course of treatment is 7-10 days.

In the treatment of bronchitis, pneumonia, the drug is taken orally 3 times a day for 10-20 ml, and also used in the form of aerosols and inhalations (without heating and using ultrasound), the course of treatment is 15-20 days.

In the treatment of otitis media, the drug is used for washing and injecting 2-5 ml 1-3 times a day into the middle ear cavity. The course of treatment is 7-15 days.

In the treatment of sinus inflammation, the drug is used to wash the nasal cavity, nasopharynx and sinuses in a dose of 5-10 ml and inject 2-3 ml into the sinuses. The procedure is repeated daily once for 7-10 days. In addition, the drug is injected into the nasal cavity in the form of turundum moistened with bacteriophage, in turn in each nasal passage and left for 0.5-1 hours. The procedure is repeated 3 times a day, the course of treatment is 7-15 days.

In the treatment of stomatitis and chronic periodontitis, the drug is used in the form of oral rinses 3-4 times a day at a dose of 10-20 ml, as well as by introducing turundum soaked in Klebsiella bacteriophage into the periodontal pockets for 5-10 minutes, the course of treatment is 7-10 days.

For conjunctivitis and keratoconjunctivitis, the drug is used 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; for purulent corneal ulcer-4-5 drops a day for 7-10 days; for purulent iridocyclitis-6-8 drops every 3 hours in combination with oral use in therapeutic dosages for 7-10 days.

In case of abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of removed pus daily once, the course of treatment is 7-10 days.

For peritonitis and pleurisy, the drug is injected into the drained cavities – abdominal and pleural through drainage tubes-once daily 20-70 ml, the course of treatment is 10-15 days.

For osteomyelitis, the drug is injected into the wound cavity through turunds, drains in the amount of 10-30 ml daily once, the course of treatment is 15-20 days.

In the treatment of suppuration of wounds, the drug is used in the form of irrigation, applications, dressings, introduction into drainage in a dose of 5-50 ml, depending on the lesion, at least once a day, the course of treatment is 10-15 days.

In the treatment of purulent-inflammatory gynecological diseases (suppuration of wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingoophoritis), the drug is used for irrigation, applications, injected into the cavities of wounds, vagina, uterus for 5-20 ml once a day for 7-10 days.

For cystitis, pyelonephritis, urethritis, the drug is taken orally at a therapeutic dose 3 times a day 1 hour before meals for 10-20 days. In the event that the bladder or renal pelvis is drained, the drug is administered through a cystostomy or nephrostomy 1-3 times a day for 20-50 ml in the bladder and 5-7 ml in the renal pelvis, the course of treatment is 7-15 days.

With gastoenterocolitis, pancreatitis, cholecystitis, and intestinal dysbiosis, the bacteriophage is taken orally in age-related dosages 3 times a day 1 hour before meals for 7-15 days (according to clinical indications). With indomitable vomiting, the drug is used in the form of high enemas 2-3 times a day for 20-40 ml. With intestinal dysbiosis, the drug can be used with normoflora preparations.

For the prevention of nosocomial surgical infections, the drug is used to treat postoperative and freshly infected wounds in a dose of 5-50 ml, depending on the lesion, once a day for 5-7 days.

Use of the drug in children under 1 year of age (including premature infants)

With gastoenterocolitis, pneumonia and sepsis of newborns, the drug is used by mouth 2-3 times a day for 3-5 ml 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enemas (through a gas outlet tube or catheter) daily once in a dose of 5-10 ml. A combination of rectal (in the form of high enemas) and oral use of the drug is possible. The course of treatment is 7-15 days (according to clinical indications). With a recurrent course of the disease, repeated courses of treatment are possible.

In order to prevent the occurrence of nosocomial infection in newborns, bacteriophage is used for epidemic indications inside 3-5 ml 3 times a day 30 minutes before feeding during the entire period of hospital stay.

In the treatment of omphalitis, pyoderma, infected wounds, the bacteriophage is applied in the form of applications of 5-10 ml 2-3 times a day (a gauze cloth is moistened with the bacteriophage and applied to the umbilical wound or the affected skin area) for 7-15 days.

The use of the drug does not exclude the use of other antibacterial and anti-inflammatory drugs.

Special instructions

Opening of vials and ampoules and the procedure for drug use is carried out in strict compliance with the rules of antiseptics.

In case of violation of the integrity of the packaging and labeling, turbidity of the drug, it is not used.

Form of production

Solution for oral, topical and external use

Storage conditions

Store in a dry place, protected from light, at a temperature of 2-8 °C

Shelf life

2 years

Active ingredient

Klebsiella bacteriophage

Dosage form

solution for oral use

Purpose

Nursing mothers as prescribed by a doctor, For adults as prescribed by a doctor, Children as prescribed by a doctor, For children from birth, Pregnant women as prescribed by a doctor

Indications

Burns, Periodontitis, Inflammation of the female genital organs, Purulent wounds, Laryngitis, Pyoderma, Cholecystitis, Stomatitis, Colitis, Pharyngitis, Pneumonia, Sinusitis, Sinusitis, Respiratory tract infections, Bronchitis, Dysbiosis