Portalac, syrup, 500ml

Composition

>

of 100 ml of syrup contains:

Active ingredient:

lactulose concentrate 66.7 g;

Auxiliary substance:

purified water.

Pharmacological action

Portalac is a laxative. Lactulose under the influence of intestinal microflora breaks down in the colon into low-molecular organic acids.

The formation of acids leads to a decrease in the pH of the intestinal contents and activation of its peristalsis. Along with this, the volume increases and the stool softens.

Under the influence of the drug, the formation of nitrogen-containing toxic substances in the proximal colon and their absorption into the systemic circulation also decreases. In addition, the movement of ammonium ions from the blood to the intestines increases.

The effect of the drug occurs 24-48 hours after ingestion.

Indications

• constipation;
• hepatic encephalopathy;
• hepatic precoma and coma (treatment and prevention).

Use during pregnancy and lactation

Lactulose can be safely used in pregnant and lactating mothers.

Contraindications

• intestinal obstruction;
• rectal bleeding;
• colo -, ileostomy;
• suspected appendicitis;
• hypersensitivity to lactulose or other sugars (lactose, galactose).

Side effects

Side effects are usually mild and reversible and are the result of exceeding the dose.

Cramps, discomfort or abdominal pain, as well as diarrhea can be eliminated by reducing the dose. Flatulence that appears at the beginning of treatment, as a rule, passes in 1-2 days.

Skin reactions (rash) have been reported.

With prolonged therapy and the use of high doses of lactulose in the treatment of hepatic encephalopathy, a violation of the water-electrolyte balance may develop, and as a result, convulsions, nausea, headache, dizziness, arrhythmia, myalgia, fatigue, weakness.

Interaction

When using therapeutic doses of lactulose, clinically significant interactions with other drugs were not observed.

However, it is not recommended to take Portalac® within 2 hours after taking another drug.

When taken concomitantly, lactulose may interfere with the action of drugs that create an unfavorable environment in the large intestine (for example, drugs containing mesalazine).

Antibiotics (neomycin) and antacids reduce the effect.

How to take, course of use and dosage

Portalak is taken orally, in the morning during or after meals, once or divided into 2 doses, washed down with water or other liquid. The dose of Portalac is selected individually. The initial dose (3 days) is:

Children under 1 year of age: 5 ml (1 teaspoon);

Children from 1 year to 6 years of 5-10 ml (1-2 teaspoons);

Children from 6 to 14 years,15 ml (1 tbsp. spoon).

Adults take 15-45 ml.

Overdose

Symptoms:  taking too high doses of the drug can cause diarrhea and a violation of the water-electrolyte balance.

Treatment:  discontinuation of the drug.

Special instructions

If constipation persists within a few days of taking the drug, or if constipation resumes after stopping taking the drug, you should consult your doctor.

Due to the presence of small amounts of sugars in the preparation (15 ml of syrup contains up to 1.7 g of galactose and up to 1 g of lactose), caution should be exercised when prescribing the drug to patients with diabetes mellitus and lactose intolerance.

Caution should be exercised when prescribing the drug to patients with gastrocardiac syndrome: treatment begins with low doses and increases them gradually to avoid flatulence.

In the treatment of hepatic encephalopathy, especially in the initial phase of therapy, other laxatives should not be used, since increased bowel emptying may lead to an erroneous conclusion about achieving an adequate dose for the treatment of encephalopathy.

Influence on the ability to drive a car or perform work that requires an increased rate of physical and mental reactions. At the recommended doses, the drug does not affect the ability to drive vehicles and mechanisms.

Form of production

Syrup

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Lactulose

Dosage form

solution for oral use

Description

For adults, Pregnant women as prescribed by a doctor, For children, Nursing mothers as prescribed by a doctor

Indications

Liver Damage, Hemorrhoids, Constipation, Dysbiosis, Enteritis, Salmonellosis