Triazavirin, 250mg capsules 20pcs

Composition

Active ingredient:

Methylthionitrooxodihydrotriazolotriazinide sodium dihydrate ( triazavirin) – 250 mg.

Auxiliary substances:

Calcium stearate – 2 mg;

Weight of the capsule contents – 252 mg;

Capsule shell composition:

Capsule (body) No. 1: titanium dioxide (E 171), yellow quinoline (E 104), yellow “sunny sunset” (E 110), medical gelatin.

Capsule (cap) No. 1: titanium dioxide (E 171), azorubin (E 122), medical gelatin.

Pharmacological action

Pharmacodynamics :

The Active ingredient of the drug is a synthetic analog of the bases of purine nucleosides (guanine) with a pronounced antiviral effect. It has a wide spectrum of antiviral activity against RNA-containing viruses.

The main mechanism of action of the drug is inhibition of viral RNA synthesis and replication of genomic fragments.

Pharmacokinetics:

After oral use, it is rapidly absorbed into the gastrointestinal tract. The maximum concentration (With_tax) is reached on average in 1-1.5 hours. With_tax at the recommended dosage regimen, it averages 4.8 mcg/ml. The blood AUC is 12.8 mcg / h * ml. The elimination half-life (Ti_/2) is 1-1.5 hours.

From 15 to 45% of the drug is excreted unchanged by the kidneys. The average calculated clearance is 246 ml/min.

Indications

Treatment of flu in adults. If necessary, the drug should be combined with the use of symptomatic drugs.

Contraindications

• hypersensitivity to the components of the drug;

• pregnancy;

• breast-feeding period;

• children under 18 years of age (efficacy and safety have not been determined);

• renal failure (efficacy and safety have not been determined).

• hepatic insufficiency (efficacy and safety not determined)

Side effects

• allergic reactions;

• dyspeptic disorders (flatulence, diarrhea, nausea, vomiting).

If the side effects get worse, or you notice any other side effects that are not listed in the instructions, you should inform your doctor.

Interaction

Interaction with analogues of purine and pyrimidine bases during antitumor therapy may lead to increased toxicity of the drug. When used concomitantly with ribavirin, a reduction in the dose of ribavirin is required.

How to take, course of use and dosage

Triazavirin® is administered orally regardless of food intake.

The drug should be taken no later than the 2nd day after the onset of the disease (the appearance of clinical symptoms),1 capsule (250 mg) 3 times a day (daily dose-750 mg) for 5 days. If necessary, the treatment can be continued for up to 7 days.

Overdose

Symptoms: nausea, vomiting, dyspeptic disorders, stomach pain.

Treatment: symptomatic therapy. If these symptoms occur, you should stop taking the drug.

Form of production

Capsules

Storage conditions

Store in a dry place protected from light, out of reach of children, at a temperature not exceeding 25 °C.

Shelf life

2 years

Active ingredient

Methylthionitrooxodihydrotriazolotriazinide sodium

Conditions of release from pharmacies

By prescription

Dosage form

Capsules

Description

For adults as directed by your doctor

Indications

Flu